We are still working on our first major results, but in the meantime, the techniques and methods we’ve been developing have given rise to some related publications from our partners.
Research Results
Dual-mode OCT/fluorescence system for monitoring the morphology and metabolism of laser-printed 3D full-thickness skin equivalents
Arooj Khalid et. al. | Biomedical Optics Express, Nov 2024 | https://doi.org/10.1364/BOE.510610
Our partners at Aston University have developed non-invasive optical systems for monitoring the growth and health of 3D lab-grown skin models. The systems developed are sensitive enough to detect minute changes in tissue health and structure without causing damage, enabling a continuous ‘window’ into biological processes. These will enable researchers to simulate treatment responses from human tissue, over days or weeks, as it responds to drugs or – for GlioLighT – photodynamic therapy.
Before GlioLighT began, the scientific basis of the GlioLighT concept was tested and proven in rats. Have a read of the preliminary work below.
Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain
Oxana Semyachkina-Glushkovskaya et. al. | International Journal of Molecular Sciences, Sep 2023 | https://doi.org/10.1364/BOE.510610
Partners at Aston University demonstrate that photosensitiser-free laser treatment can effectively suppress glioblastoma growth in rats, increasing survival rate from 34% to 64%. This approach was eventually refined and adjusted into the GlioLighT project.
